Endocrine Abstracts

The majority of circulating total 25-hydroxi-D-vitamin (t-25OHD) is bound to proteins – 90% to vitamin D binding protein (DBP) belonging to the alfa-2-globulin (a-2gl) fraction and 10% to albumin (ALB). Nowadays the t-25OHD level is the most accepted marker of vitamin D supply in physiological states. Our aim was to investigate the t-25OHD concentration in clinical conditions with low albumin levels.Methods: Seventy-three patients (39 men, 34 women;...

Parathormone (PTH) is the marker for bone remodelling in chronic renal failure. The biologically active PTH 1–84 intact molecule (PTHibio) is supposed to better correlate with the degree of remodelling than PTH-intact (PTHi) which also binds to the 1–34 fragment. Our aim was to examine the PTH levels in dialysed patients with these two methods, considering also the total 25-hydroxi-vitamin-D (t-25OHD) levels.Methods: patients (age 63±15 ye...

Background: The most reliable biochemical markers in the follow-up of medullary thyroid carcinoma (MTC) are serum calcitonin (CAL) and carcinoembrional antigen (CEA).Case: A 82 years male presented with rapidly growing neck tumour in April 2008. The patient underwent total thyroidectomy with lymph node dissection (June 2008). The pathology revealed MTC localized only in the left lobe (pT3NoMx), the immunohistology showed CAL-, synaptophysin, chromogranin...

We report the case of a 55 years old female patient with parallel appearance of mucoepidermoid carcinoma and papillary thyroid carcinoma. She had autoimmune adrenal insufficiency and a pulmonary adenocarcinoma cured by lobectomy and external irradiation six years before. She had been referred to our department because of a rapidly growing thyroid nodule. Aspiration cytology suspected papillary tumor and a tumor of non-thyroid origin as well. Thyroidectomy and bilateral neck ly...

Familial isolated pituitary adenoma (FIPA) occurs if two or more members of a family develop pituitary adenoma with no features of multiple endocrine neoplasia type 1 or Carney complex. FIPA is an autosomal dominant disease with incomplete penetrance. FIPA families can be divided into two distinct groups based on genetic and phenotypic features. In 20% of FIPA families mutations have been identified in the aryl hydrocarbon receptor interacting protein (AIP) gene. The AIP-posit...